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Early-stage research, access by request

AION

Open hypothesis generation for longevity, cancer, and the biology of aging.

Built on HGE Core. A research scope of 12 pillars spanning the 12 hallmarks of aging and 10 hallmarks of cancer. Structured, verifiable hypotheses with confidence and novelty scoring.

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Platform stats

12

Research pillars

12 + 10

Hallmarks mapped

HGE

Core adapter

CC BY 4.0

Hypothesis licence

RESEARCH PILLARS

Twelve hypothesis engines. One reasoning platform.

Each pillar is an independent hypothesis generation module connected to HGE Core. The hallmark and drug-repurposing engines are live in testing; the remaining pillars are in development. Hypotheses are scored for confidence and novelty and published under CC BY 4.0.

01

Hallmark Engine

Cross-hallmark hypothesis generation for any intervention against the 12 hallmarks of aging and 10 hallmarks of cancer.

02

Drug Repurposing

Structured longevity and cancer repurposing hypotheses for approved drugs. Confidence and novelty scoring per compound.

03

Stem Cell & Reprogramming

Partial reprogramming, iPSC, and stem cell exhaustion hypotheses. Yamanaka factor analysis.

04

Epigenetic Clocks

DNA methylation clock analysis and intervention impact prediction across Horvath, GrimAge, and DunedinPACE models.

05

Senolytic Discovery

Compound mapping against senescent cell types and safety profiles. Dasatinib, quercetin, navitoclax coverage.

06

Cancer–Longevity Intersection

Shared pathways between aging and cancer: synergies, paradoxes, and mechanistic overlaps.

07

Pathway Network Mapper

Interactive biological pathway network with intervention overlays across mTOR, AMPK, IGF-1, sirtuin axes.

08

Cross-Species Intelligence

Mechanism translation from naturally long-lived species (naked mole rat, Greenland shark, Hydra) to humans.

09

Clinical Trial Gap Finder

Identifies critical experiments that have not yet been conducted. Surfaces white-space in the trial landscape.

10

Combination Optimizer

Synergy, conflict, and safety analysis for intervention stacks. Rapamycin + metformin + senolytic combinations.

11

Biomarker Discovery

Validated and candidate biomarkers of biological age and intervention response.

12

Open Commons

Submit, evaluate, and publish longevity hypotheses openly under CC BY 4.0.

López-Otín et al., Cell 2023

12 Hallmarks of Aging

  1. 1Genomic Instability
  2. 2Telomere Attrition
  3. 3Epigenetic Alterations
  4. 4Loss of Proteostasis
  5. 5Disabled Macroautophagy
  6. 6Deregulated Nutrient Sensing
  7. 7Mitochondrial Dysfunction
  8. 8Cellular Senescence
  9. 9Stem Cell Exhaustion
  10. 10Altered Intercellular Communication
  11. 11Chronic Inflammation
  12. 12Dysbiosis

Hanahan, Cancer Cell 2022

10 Hallmarks of Cancer

  1. 1Sustaining Proliferative Signaling
  2. 2Evading Growth Suppressors
  3. 3Resisting Cell Death
  4. 4Enabling Replicative Immortality
  5. 5Inducing Angiogenesis
  6. 6Activating Invasion & Metastasis
  7. 7Reprogramming Energy Metabolism
  8. 8Evading Immune Destruction
  9. 9Unlocking Phenotypic Plasticity
  10. 10Nonmutational Epigenetic Reprogramming
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